David Heinemeier Hansson (DHH) is the creator of Ruby on Rails and the co-founder of 37signals, the company behind Basecamp, HEY, and ONCE. He has spent 25 years building a software business around one condition: no one gets to tell him what to do.

Jason Fried hired him as a contractor out of Copenhagen for $15 an hour. He built the first version of Basecamp with just 10 hours a week — 380 hours in total — and still credits the shortage of time for how good it turned out. He does not trust himself with unlimited resources. Nobody should, he argues. Give a team too much money and too many people and it will build a blob.

Forty-some venture firms came calling in 2005. The only investor 37signals ever said yes to was Jeff Bezos, who accepted a term sheet priced so absurdly high they were certain he would walk. They have been sending him dividend checks ever since. Basecamp has been rewritten three times, and the original 2004 version — discontinued in 2010 — still runs and still makes millions in profit.

His marketing strategy, borrowed from Kathy Sierra, hasn't changed in two decades: you can't outspend the giants, but you can out-teach them. His product test hasn't either. He builds the thing he wants for himself, and once he'd rather use it than anything else available, he assumes he isn't alone. That's how Ruby on Rails started. It's how Omarchy started too — the Linux distribution he’s spent thousands of hours making and gives away.

No investors. No board. And now, with Omarchy, no customers. He calls that last step a retirement from capitalism: still making things, still sharing them, with nobody holding a claim on his time.

Show notes: https://www.davidsenra.com/episode/david-heinemeier-hansson

Made possible by

Ramp: https://ramp.com

AppLovin: https://applovin.com/senra

HubSpot: https://hubspot.com/startups

Deel: https://deel.com/senra

Chapters

(00:00:00) Cutting Rework From 50,000 Words To 25,000

(00:02:54) Basecamp Was Built In 380 Hours

(00:06:46) Unlimited Resources Build A Blob

(00:10:22) Terminator Beats Avatar By A 1000x

(00:15:24) The Printer DHH Never Wants To Upgrade

(00:17:31) Millions In Profit From 16 Year-Old Software

(00:20:10) The Beauty Of A Finished Product

(00:22:54) I Would Quit Before Working In An Office

(00:25:41) Four Uninterrupted Hours Or The Day Is Lost

(00:31:21) Tobi Lütke Saw The AI Future First

(00:38:51) Apple Pissed Him Off Enough To Switch

(00:42:47) The 19 Year-Old Who Beat Apple

(00:47:16) If Nobody Else Will Build It, I Will

(00:52:02) The Need For Control, Independence, And Freedom

(00:53:44) Chef's Choice, Not A Construction-Kit Burger

(00:56:50) A New Computer Ready In 2 Minutes

(01:00:33) A Cheaper Mac Will Never Win

(01:02:27) The Best Ideas Sound Stupid At First

(01:03:47) Out-Teach Your Competition

(01:06:57) The Algorithms Broke Reciprocity

(01:10:53) No Investors Is Freedom. No Customers Is Transcendence.

(01:13:25) No One Gets To Tell Me What To Do

(01:16:49) Your Moral Obligation To Buy A Ferrari

(01:23:19) Costs Are The Only Thing You Control

(01:26:49) Bezos Paid For The Promise

(01:30:17) The Confidence To Say No To Everyone

(01:32:59) The Day A Third Of The Company Left

(01:36:49) Marc Andreessen Came To Help

Learn more about your ad choices. Visit megaphone.fm/adchoices

Tyler Cowen (Website, X, Marginal Revolution, Conversations with Tyler) is an economist at George Mason University, leads the Mercatus Center, and is the author of many books including The Great Stagnation and Average Is Over. He has blogged nearly daily at Marginal Revolution for over 20 years, has interviewed hundreds of world-experts on Conversations with Tyler, and runs Emergent Ventures, a prolific grants program that has funded multiple Dialectic guests.

Nabeel S. Qureshi (Website, X, Substack) is an entrepreneur, writer, and researcher. He runs a stealth startup. Previously, he was a Visiting Scholar at Mercatus and spent nearly eight years at Palantir. He writes some of my favorite essays, including "What Makes Art Great" and "Rented Virtue", and was previously a guest on Dialectic for episode 13: "The Will to Care."

Tyler and Nabeel are good friends, and given how prolific Tyler is, I decided to use Nabeel as an entry point and interview them together. We discuss sacred commitments, AI acceleration, mentorship, friendship, and more, but I focused the majority of the conversation on art and aesthetics. Tyler and Nabeel are unlikely aesthetes given their day jobs, but in fact take art deeply seriously. They have a shared love for and similar tastes in art, music, and film, in particular. We discuss strange and beautiful art, aesthetic stagnation, and a wide range of favorites: The Beatles, Mozart, Mondrian, Springsteen, Lana Del Rey, Kanye West, Cassavetes, The Sopranos, Apichatpong Weerasethakul, and more.

Please enjoy, and thank you for supporting, listening, and watching through fifty episodes of Dialectic. I can't wait for the next fifty!

Transcript and all links: dialectic.fm/tyler-nabeel

---

Dialectic is presented by Notion. Notion is an AI-powered connected workspace where teams think together and create their best work. Learn more about Notion's new developer platform and workers here. You can learn more at notion.com/dialectic.

Timestamps:

• (0:00) Opening Highlights
• (1:18) Intro to Tyler & Nabeel
• (3:02) Thanks to Notion
• (4:38) Start: Sacred Commitments, AI, Markets, and Acceleration
• (20:23) How Art Moves Us
• (27:08) "Beauty," Strangeness, Great Art, Music, and The Beatles
• (44:09) Film, Critics, Learning to Appreciate Depth, More Music, "Lowbrow" Art
• (1:02:25) New Aesthetics, Sources of Inspiration, Optimism & Pessimism
• (1:11:22) The Internet & Twitter's Virtue, Group Chats, and Cities
• (1:21:35) Mentors, (Possibly Quitting) Writing Books, Friendship
• (1:34:54) Interviewing, Identifying Talent, and Agency
• (1:47:21) Closing Questions
• (1:53:38) Thanks Again to Notion

Is Islam Compatible with the West? Get your discounted early bird tickets now before they sell out: https://winstonmarshall.eventbrite.co.uk

I cannot wait for you to join us in London for one of the most important debates of our time.

In this episode of The Winston Marshall Show, I sit down with economist, author, and columnist Tyler Cowen for a conversation on artificial intelligence, the race between America and China, cyber warfare, and why the AI revolution will reshape every aspect of modern life.

We explore the growing battle between the Trump administration and leading AI companies such as Anthropic and OpenAI, the risks of AI-driven cyber attacks, national security, effective altruism, and why Cowen believes the world is entering the most significant technological transition since the Industrial Revolution. We also discuss whether AI represents a greater geopolitical challenge than nuclear weapons, how governments should regulate it, and why the coming years could be both extraordinarily dangerous and extraordinarily prosperous.

The conversation also examines the future of work, economic growth, surveillance, healthcare, longevity, education, and whether AI will deepen state control or instead empower individuals. Cowen explains why he believes AI could eradicate many diseases, transform productivity, and fundamentally alter the relationship between governments, corporations, and ordinary citizens.

Finally, we turn to Britain's economic decline, immigration, productivity, energy policy, debt, and why Cowen believes the UK urgently needs a new economic direction before its long-term decline becomes irreversible.

WATCH THE EXTENDED CONVERSATION HERE: https://www.winstonmarshall.co.uk/

Chapters

00:00 Introduction

02:10 AI Cyber Warfare & Why The Next Few Years Matter

05:00 Trump, Anthropic & Who Controls AI?

10:20 Can Britain Defend Itself In The AI Era?

15:19 Why AI Is Like World War II

19:20 Effective Altruism & The Future Of AI

23:23 Is AI More Dangerous Than Nuclear Weapons?

27:04 Will AI Cure Disease & Extend Human Life?

30:00 AI, Surveillance & The Risk Of Totalitarianism

35:00 Jobs, Education & How AI Will Change Work

40:31 AI, Space & The Next Global Arms Race

45:00 AI, Religion & The Future Of Faith

49:07 Is Britain Already In A Debt Crisis?

What we covered:

• The dangers of accumulating learning debt: the gap between what you can do and what you need to be able to do.
• If you miss building up your foundational skills in school or sports, you can get by for a while. You develop some compensatory strategies, like favoring your forehand over your backhand, or using ChatGPT to write all your school essays.
• But learning debt is like any other kind of debt: it accrues interest and eventually comes due. Over time, the workarounds become more complex. The cognitive load increases. You start avoiding situations that expose the gap, and this is where you hit your ceiling. You can’t pursue an engineering degree if you can’t do algebra. You can’t be competitive in tennis if you can’t hit with your backhand.
• Learning debt often begins because of a lack of oversight by adults. Parents, teachers, and even coaches sometimes think they’re being nice not telling you that you need to work on your weaker side, or you need to stop using a calculator on your math problems. It feels like nagging, and it can create conflict between adults and learners. So they let it slide.
• But this failure to hold the line early on inhibits students’ future potential. And when it occurs across many students across many schools, it degrades the whole educational system – leading to the current situation in which many students are totally unprepared for the rigors of college.

Outline:

0:00 - Introduction

2:04 - Course phases: instruction, final review, final exam, remediation if needed

5:25 - Generating full-length SAT exams for our prep course

6:53 - Loosening up the gravity throttle for high-performing students

14:59 - Aptitude is measured by accuracy rate

18:07 - Accuracy correlates first with aptitude, second with conscientiousness

21:35 - Assessment vs. non-assessment accuracies

23:43 - Propagating accuracy through the knowledge graph

24:27 - Hidden skill gaps force bad compensations

25:27 - Sports make skill deficits and bad compensations obvious

33:38 - The Math Academy system holds you accountable for every skill

34:18 - Completing the square: a common skill deficit with temporary workarounds

36:15 - Reliance on Desmos undermines students’ ability to graph functions

37:38 - You need to know your multiplication facts for factoring

38:13 - Foundational deficits are usually caused by lack of adult oversight

38:52 - Shoring up foundations is effortful but has huge ROI

40:40 - Filling in missing foundations makes kids so much more confident

41:12 - Missing foundations stall learning and drive cheating

42:12 - Faking competence backfires downstream

45:33 - The truth hurts but is the kindest thing in the long run

46:26 - Learning debt eventually comes due, with students paying the biggest price

47:12 - Kicking the can down the road in education

49:46 - The cost of a broken education system

Follow on X:

Math Academy - https://x.com/_MathAcademy_

Justin Skycak - https://x.com/justinskycak

Jason Roberts - https://x.com/exojason

0:00 - Introduction

4:00 - Applying the MA Way to X Growth

7:40 - Status of the ML Course and its Kick-Ass Coding Projects (Part 1)

25:50 - Jason's Near-Infinite List of Important Things

34:20 - The ML Course Has Been a Massive Undertaking

42:10 - Breadth-First Development

44:30 - Status of the ML Course and its Kick-Ass Coding Projects (Part 2)

50:15 - Why Math Academy Needs To Do a CS Course

56:45 - The Never-Ending Stream of Confusion

1:00:30 - The Story of Eurisko, the Most Advanced Math/CS Track in the USA

1:24:20 - Intuition Through Repetition: Machine Learning Edition

1:29:40 - The Importance of Spaced Review

1:43:30 - Upcoming Course Roadmap

1:47:40 - Spaced Repetition 2.0: Accounting For and Discouraging Reference Reliance

1:54:45 - Overhelping: A Pathology of the Over-Involved Parent/Tutor

1:59:21 - Yes, You Need to be Automatic on Math Facts (and Yes, Rapid-Fire Training is Coming)

2:04:55 - What Happens When Students Don't Know Their Math Facts

2:05:50 - The Horror of Attempting to Teach a Class When Students Have Multi-Year Deficits in Fundamental Skills

2:11:30 - Integrating Coding Into the Math Curriculum

2:18:00 - Combining Math and Coding is the Closest Thing to a Real-Life Superpower

2:18:55 - Creating a Full Math Degree and Getting Full College Credit

2:22:15 - The Power of Pre-Learning: The Greatest Educational Life Hack

Follow on X:

Math Academy - https://x.com/_MathAcademy_

Justin Skycak - https://x.com/justinskycak

Jason Roberts - https://x.com/exojason

What we covered:

-- How bureaucracies instinctively reject new ideas like an immune system attacking a foreign organ, and what it takes to keep your project from being "spit out." Concrete example: how Jason & Sandy muscled past institutional resistance to get 8th graders passing AP Calc BC.

-- Every system inevitably decays into mediocrity unless someone fights to keep the standards high. The way you keep people, systems, and projects moving is by "horsing" them forward. Concrete example: how Justin kept 8th graders passing AP Calc BC, and what it looks like when a school succumbs to the gravity of mediocrity.

-- Justin's math self-study journey in high school: grinding math like a video game, running a secret self-study op inside traditional classes, taking talent development seriously while simultaneously hitting his head on every ledge and making every rookie mistake. Ups and downs, lessons learned, with tons of concrete examples.

Timestamps:

00:00:00 - Intro: Willing Things Into Existence

00:11:43 - How Jason & Sandy Willed Math Academy Into Existence

00:36:45 - Fighting The Gravity of Mediocrity

01:02:29 - Case Studies in Educational Dysfunction

01:21:53 - The Birth of Justin’s Self-Study Madness

01:50:48 - Self-Studying on the Sly During School

02:02:41 - The Highs & Lows of High School Research

02:22:38 - Outro: Paving the Path with Math Academy

Follow on X:

Math Academy - https://x.com/_MathAcademy_

Justin Skycak - https://x.com/justinskycak

Jason Roberts - https://x.com/exojason

Follow Justin on Twitter: https://x.com/justinskycak

0:00 - What Would a Tutor Do, If Their Life Depended On It? (Part 1)

5:47 - Find Your North Star: Why Justin Quit His Data Science Job to do Math Tutoring Full Time

11:23 - Getting "Inside the Trade"

19:31 - What Would a Tutor Do, If Their Life Depended On It? (Part 2)

27:28 - Efficient Learning Techniques are Obvious if You Think About Athletics

33:45 - Enjoyment is a Second-Order Optimization

39:50 - We Need to Stay Hardcore, But Become Less Harsh

51:14 - Math Academy is Like "Yuri's Gym"

59:06 - Vision for the Future of Math Academy

1:14:23 - Goal Setting/Advising and Communicating Progress

1:24:58 - If All You Show Up With is AP Calculus, You're Probably Outgunned

1:51:08 - The Meta-Skills that Kids Need to Work Effectively on Math Academy

2:08:54 - How to Help Students Maintain Successful Learning Habits While Working Independently

2:32:29 - Overhelping: A Common Failure Mode of Well-Intentioned Parents/Tutors

Follow on X:

Math Academy - https://x.com/_MathAcademy_

Justin Skycak - https://x.com/justinskycak

Jason Roberts - https://x.com/exojason

In this episode, Justin Skycak, Chief Quant, Director of Analytics at MathAcademy.com will walk us through some principles of cognitive science and how they can help us think about planning our instruction and planning practice for our students.

Show Notes:
Road to Reading Webpage
SoR Resource Page
Season 2-episodes
Season 3-episodes

hey folks first time posting this sort of interview as a podcast (shout out the three anon on twitter that requested it).

now that I think of it the format does make sense since me and the interviewee are mostly chatting and exchanging ideas!

will be posting more of these in the future!

in this episode I had the pleasure of spending not 1 but 2 days interviewing the learning legend justin skycak.

we've talked about his quite impressive self-learning journey (3000h of math in high school) all the way to how he hand curated the initial knowledge graph for math academy to make that process more efficient.

I like justin because I understand his inner desire for learning.

I had the exact same “awakening” let’s say in my tiny bedroom when I was a teenager. I realized while doing some homework that I loved learning and found an immense sense of peace within it.

this realization kind of got lost in the midst of winter depression for a while until it got awoken again with a burning flare that never died down since (more trauma dump here).

this understanding that there is a meta-learning-skill is so fun because then the whole world kind of open up for you.

you encounter a hard problem you don’t know how to even get started? → great let’s use “learning”.

you got an opportunity that you are under prepared for? → great let’s use “learning”.

you want to make something seemingly impossible happen? → great let’s use “learning”.

what I like about justin’s story is that it is very concrete and touch math which has far reaching usefulness in life.

so here is the very lively 3h discussion where we touch these topics:0:00:00 - intro: 0:02:10 - justin background 0:05:45 - 3000h math self study in high school0:11:45 - what a day looked like for that 3000h stretch0:16:10 - meta-learning vs pure math learning0:21:50 - when did you get into cognitive neuro?0:29:55 - how did the fundamental math helped in your research projects0:43:10 - what does the math academy learning system looks like0:47:34 - how did you guys build the 2000 topic knowledge graph1:01:15 - would LLM be useful as an interface to that knowledge graph for the students?1:10:46 - how does the FIRe spaced repetition algorithm works?1:17:34 - does the same knowledge graph structure would work for physics? or other topic?:1:34:05 - how do you understand the subject vs the curiculum1:35:50 - is there a connection between studying math and learning a sport?1:42:00 - do you think in math doing and teaching requires different skills?1:56:25 - could you get understanding without automaticy?2:05:35 - do you see any upside of confusion in learning?2:14:11 - learning math as an adult?2:19:20 - how to fill the motivation gap after learning the fundamental?2:24:10 - how should teaching math for kids and adults balance fundamentals and creativity?2:33:55 - is it ever too late to learn math seriously?2:46:00 - mastery learning vs ultra learning2:51:30 - top-down vs bottom-up2:53:40 - mastery learning for domain without a structured hierarchical structure?2:56:30 - neurodivergence / adhd for structured math learning?3:06:20 - amateur mathematician augmented with technology will be able to contribute to research?3:14:37 - what are you most excited about right now in term of learning

enjoy my guys! :)

• Follow Scraping Bits on Twitter: ⁠⁠https://x.com/scrapingbits⁠⁠
• Your Host, DeGatchi: ⁠⁠https://x.com/DeGatchi⁠⁠
• Guest Speaker: ⁠⁠https://x.com/justinskycak

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Keywords: math, mathematics, solo auditor, public auditing platforms, private audits, scalability, freedom, Scraping Bits podcast, blockchain technology, audit industry, flashbots, reverse engineering, cybersecurity, infosec, mev, mev bot, quant.

The subject of when the best time is to take steps to improve our relationship with food or recover from an eating disorder comes up a lot when I’m listening to people who reach out to me wanting to make changes. So today I’m really stoked to say that Kathryn Hansen, Author of Brain Over Binge is joining us here again to talk about whether or not there really is such a thing as the best time to begin recovery, and how things like stress or a high workload can influence our approach to the journey. 

Book a Call with Marcus Here: https://form.jotform.com/240493269367062

Strong Not Starving YouTube: https://youtube.com/@strongnotstarving?si=zzmTveIdGUD0omuM

Stay up to date with Strong Not Starving events and resources ⬇️⬇️⬇️  https://preview.mailerlite.io/forms/2452616/190543834178913405/share

Website: www.strongnotstarving.com

Kathryn Hansen, author of Brain Over Binge, joins me on the podcast today to discuss:

Processing an Urge

Exercise in Recovery

Believing Recovery is Possible

& More. 

So excited to have her on. She was the first person that introduced me to the idea that binging was not just inherently me. That it could be coming from a habitual place instead. While I would recover for years after reading her book, Brain Over Binge was one of the major catalysts in my recovery.

💚Kathryn's Website:

https://brainoverbinge.com

For more information on private coaching, group coaching, free resources, & more go to

https://www.bingebreakers.com

Instagram:

https://www.instagram.com/bingebreakers_bulimia/

DISCLAIMER

This recording is not nor is intended to be utilized as medical advice or a medical diagnosis. If you think you are in need of medical attention or treatment, please seek it immediately. This recording is intended to offer advice to those struggling with bulimia based on my own experience, my client's experiences, and what I’ve found to work. This recording will also contain sensitive subjects such as binging and purging, weight, & depression. Please listen at your own discretion and do what you think is best for you. 

I am a coach. Not a doctor, therapist, or any other medical professional. I cannot diagnose conditions or prescribe treatments. If you think you need more advanced help, such as therapy, ED treatment, or you are a risk to your own health, please seek it immediately. 

To find more resources on eating disorders please visit: https://www.nationaleatingdisorders.org/help-support/contact-helpline

Kathryn Hansen, author of Brain Over Binge is joining us for today’s episode  to talk about the 8 most common ways our mind tries to justify binge eating.
Binge eating is one of those things that can make any bad situation worse, but that’s not what our mind  tries to convince us of in the moment, right? No matter how many times we muster the resolve to say “never again”, when struggling with binge eating, it can start to feel like when urges get strong, our mind comes up with a seemingly reasonable reason to justify a binge. So that’s what Kathryn and I are talking about today!

Strong Not Starving Workshop Pack: https://www.mkaincoaching.com/strong-not-starving-form

Brain Over Binge on Instagram: https://instagram.com/brain_over_binge?igshid=YmMyMTA2M2Y=

M. Kain Coaching on Instagram: https://instagram.com/mkaincoaching?igshid=YmMyMTA2M2Y=

BrainOverBinge.com: https://brainoverbinge.com

Book a Call with Marcus Here: https://form.jotform.com/240493269367062

Strong Not Starving YouTube: https://youtube.com/@strongnotstarving?si=zzmTveIdGUD0omuM

Stay up to date with Strong Not Starving events and resources ⬇️⬇️⬇️  https://preview.mailerlite.io/forms/2452616/190543834178913405/share

Website: www.strongnotstarving.com

Patrick McKenzie (patio11) is joined by Casey Handmer, rocket scientist turned CEO of Terraform Industries. Casey discusses the rapid advancements in solar power, the bureaucratic challenges of NASA, the incomprehensible success of SpaceX, and the evolving energy landscape. Casey touches on his experiences at JPL revealing how the organization’s fear of waste and rigid processes often stifle innovation and efficiency.

The conversation then shifts to Terraform Industries' mission to create synthetic natural gas from sunlight and air, potentially revolutionizing the energy sector. The conversation dives into the complexities of large-scale systems, from space exploration to renewable energy, offering insights into how innovation and smart policy can shape a more sustainable and prosperous future.

–
Full transcript available here: https://www.complexsystemspodcast.com/episodes/solar-economics/
–
Sponsors:  Safebase 

Ready to save time and close deals faster? Inbound security reviews shouldn’t slow down your team or your sales cycle. Leading companies use SafeBase to eliminate up to 98% of inbound security questionnaires, automate workflows, and accelerate pipeline. Go to safebase.io/podcast 

–

Links:

• Terraform Industries: https://terraformindustries.com/
• SpaceX: https://www.spacex.com/
• JPL: https://www.jpl.nasa.gov/
• Book: The Alchemy of Air: https://www.goodreads.com/book/show/3269091-the-alchemy-of-air

–

Twitter:
@patio11
@CJHandmer

-
Timestamps:

(00:00) Intro

(00:25) Casey’s startup: Terraform Industries

(00:48) The rise of solar power

(02:19) Solar power vs. traditional energy sources

(05:18) Economic and industrial impacts of solar

(09:02) Challenges in aviation and energy

(19:39) The role of policy in clean energy

(22:30) Sponsor: Check

(23:41) Casey’s experience at NASA and JPL

(34:17) SpaceX, Elon Musk and the US private space actors

(44:05) Solving problems and workplace politics

(45:10) Spreadsheets create their own reality, film at eleven

(48:35) Organizational challenges at NASA

(49:40) Challenges of innovation in bureaucracies

(51:07) The role of NASA and government in innovation

(55:25) The housing theory of everything

(58:36) Empowering employees for success

(01:02:41) Terraform Industries’ vision

(01:07:28) The future of energy and carbon neutrality

(01:10:52) The importance of hydrocarbons in aviation

(01:15:47) Challenges with hydrogen as a fuel

(01:18:21) Development of synthetic fertilizers

(01:21:54) Environmental considerations on industrial progress

(01:22:55) Wrap

"I do not believe the United States can now claim to be a liberal political culture". That's just one of the big claims made by the philosopher John Gray during our wide-ranging discussion of the history of philosophy, liberalism - and of course, cats.

John does not think liberalism has “gone astray”; he thinks it contains the seeds of its own destruction from the beginning. We argue about this first, before turning to his new book Feline Philosophy, which I see as a natural extension of his earlier work. 

Gray points out that "cats are happy being themselves, while humans try to be happy by escaping themselves." Inspired in part by observations of the life and death of his own cat, Julian, Gray urges us to pursue a cat-like ethical position. This means abandoning the search for meaning outside of ourselves, and instead seeking to live in a way that aligns with our own nature.

Here Gray suggests we can draw on Taoism, Spinoza and other strands of thought. Self-consciousness and a fear of death have cursed humans with the need to make a story of our lives, rather than to simply live it.Our goal should not be to create ourselves through projects, he argues, so much as to realize our own nature, and live by it. Philosophy is not the answer, says this philosopher. "Posing as a cure," Gray says, "philosophy is a symptom of the disorder it pretends to remedy".

Along the way, John and I discuss the rise of what he calls "hyper-liberalism"; the impact of 1989; Joseph Conrad; the Genesis myth; American libertarianism, the impact of the lockdown on our our ability to distract ourselves, liberalism foundations in Christianity; life after Covid; and of course, our cats - Julian (his) and Cookie (mine).

John Gray

John is one of the leading and one of the most provocative philosophers of our age, having retired from his position as School Professor of European Thought at the London School of Economics and Political Science. Gray is a prolific contributor to and reviewer for the The Guardian, Times Literary Supplement and New Statesman.

Works 

Feline Philosophy: Cats and the Meaning of Life (2020)

“Two faces of On Liberty” (2020)

Mill on liberty: a defence (1983, 1996)

"The crisis is a turning point in history", New Statesman, 23 April 2020

“The problem of hyper-liberalism”, TLS, 30 March, 2018

Postliberalism: Studies in Political Thought (1993)

Two Faces of Liberalism (2000)

Gray's Anatomy: Selected Writings (2009)

False Dawn: The Delusions of Global Capitalism (1998)

The Dialogues Team

Creator: Richard Reeves

Research: Ashleigh Maciolek

Artwork: George Vaughan Thomas

Tech Support: Cameron Hauver-Reeves

Music: "Remember" by Bencoolen (thanks for the permission, guys!)

Casey Handmer is the founder of Terraform Industries, a company that is turning CO2 into natural gas through solar electricity. He's an astrophysicist with a PhD from Caltech who has worked on frontier technologies at NASA and Hyperloop. He's also a husband and the father of three kids. Including a newborn! In today's conversation we discussed:

* Productivity and priorities

* How to make it work without a support structure

* How to work on having optimism be the default so you can build a better future

* How he and his wife (also an astrophysicist and engineering leader) manage a busy household and three under the age of five

* The importance of long-term projects, both professionally and personally

* The worst parenting advice he's ever given and received

* His kids and their relationship with technology

Listen or watch Startup Dad on Apple, Spotify, YouTube, and Overcast.

—

Where to find Casey Handmer

LinkedIn: https://www.linkedin.com/in/casey-handmer-60183262/

Twitter / X: https://twitter.com/CJHandmer

Casey's Blog: https://caseyhandmer.wordpress.com/

Casey and Christine's Podcast

Where to find Adam Fishman

Newsletter: startupdadpod.substack.com

Newsletter: www.FishmanAFNewsletter.com

LinkedIn: https://www.linkedin.com/in/adamjfishman/

Instagram: https://www.instagram.com/startupdadpod/

—

In this episode, we cover:

[1:46] Welcome

[2:01] Caesy’s Professional background

[7:04] Casey’s wife & kids

[10:28] How did you meet your wife?

[14:26] Support structures (or not having any!)

[17:21] Getting joy vs. minimizing work

[20:51] Most surprising thing about being a dad

[24:13] Worst parenting advice Casey has ever given and received

[30:37] Optimism as a default

[36:00] Where do you not align with your wife?

[38:46] Kids relationship to technology

[42:19] How to follow along with Casey’s journey

[43:21] Rapid fire round

[53:39] Thank you

—

Show references:

Snoo: https://www.amazon.com/SNOO-Smart-Sleeper-Happiest-Baby/dp/B0716KN18Z

Terraform Industries: https://terraformindustries.com/

NASA: https://www.nasa.gov/

Hyperloop: https://www.hyperlooptt.com/

CalTech: https://www.caltech.edu/

JPL: https://www.jpl.nasa.gov/

Kip Thorne: https://en.wikipedia.org/wiki/Kip_Thorne

Planet: https://www.planet.com/

LARP: https://en.wikipedia.org/wiki/Live_action_role-playing_game

Rubik's cube: https://rubiks.com/en-US/

Lego: https://www.lego.com/en-us

Kid-safe knives: https://www.amazon.com/Tovla-Knives-3-Piece-Nylon-Baking/dp/B0711QYPJD/

Tesla Model Y: https://www.tesla.com/modely

Tesla Cybertruck: https://www.tesla.com/cybertruck

—

For sponsorship inquiries email: podcast@fishmana.com.

For Startup Dad Merch: www.startupdadshop.com 

Production support for Startup Dad is provided by Tommy Harron at

http://www.armaziproductions.com/

Dr Marina Bluvshtein is a renowned researcher and archivist of Adler’s life. She shares how the events of his life shaped the development of his theory we know as Individual Psychology. In this conversation, Marina shares Adler’s own parenting journey and how his theory, and that of Rudolf Dreikurs, came together to still be an evolving, optimistic parenting model.  

Links mentioned in the show: 

Learn more about the Adlerian Summer School known as ICASSI 

Check out the offerings at the Adler Academy of Minnesota

And write directly to Dr Bluvshtein at mbluvshtein@adler.edu to learn more about Adlerian training events in Chicago, Vancouver and online.   

On social media, you can find Dr Bluvshtein on FB.

Hosted on Acast. See acast.com/privacy for more information.

With Lion’s Roar’s free “Wisdom of Pema Chodron” Summit about to launch, we’re sharing Andrea Miller’s story abouts Pema Chodron and her advice on how to “walk the walk” of a spiritual person, and what being a “fake” spiritual person really means. Visit lionsroar.com to register.

Renowned author and meditator Ani Pema Chodron answers questions and gives advice on the practice of tonglen. Tonglen is the exchange of self for others and is considered one of the greatest practices within Mahayana Buddhism. With characteristic good humor and kindness Ani Pema addresses the difficulties of the practice, its counterintuitive approach to transforming habitual thinking and it's profound result. Theme music by Matt Quentin

Host Michael Taft talks with neuroscientist and meditator Ruben Laukkonen about the phenomenology of the insight experience, how the sequence of deepening meditative practices maps onto the model of predictive processing in the human brain, the Eureka heuristic, what neuroscience can tell us about the deconstructive model of meditation, the science of cessations, and much more.

Ruben Laukkonen is a postdoctoral fellow at the Vrije Universiteit Amsterdam and lecturer at Amsterdam University College. Ruben seeks to uncover an empirically grounded and experientially authentic understanding of meditation, insight, and non-duality. Using a combination of neuroimaging, machine learning, and phenomenology, he is investigating some of the rarest states of consciousness available to human beings. Ruben has an eclectic contemplative background, including traditions such as Zen, Advaita, and Theravada.

Learn more at https://rubenlaukkonen.com/

Help to support the Deconstructing Yourself podcast at Patreon.

Or give a one-time donation: Donate

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Brought to you by Allbirds incredibly comfortable shoes, Wealthfront high-yield savings account, and Shopify global commerce platform providing tools to start, grow, market, and manage a retail business. 

Derek Sivers (@sivers) is an author of philosophy and entrepreneurship, known for his surprising, quotable insights and pithy, succinct writing style. He is a former musician, programmer, TED speaker, and circus clown, who sold his first company, CDBaby, for $22 million and gave all the money to charity.

Derek’s books (How to Live, Hell Yeah or No, Your Music and People, Anything You Want) and newest projects are at his website: sive.rs. His upcoming book is Useful Not True.

Please enjoy!

P.S. To follow the exact step-by-step "Tech Independence" instructions from Derek, please visit sive.rs/ti.

*

This episode is brought to you by Allbirds! Allbirds are incredibly comfortable shoes, sustainably made, with design rooted in simplicity. I’ve been wearing Allbirds for the last several months, and I’ve been alternating between two pairs. I started with the Tree Runners (in marine blue, if you’re curious), and now I’m wearing the Tree Dashers, and the Tree Dashers are my current “daily driver.” I stick with the blue hues, and the Dashers are in buoyant blue. The color pops, and I’ve received a ton of compliments.

The Tree Dasher is an everyday running and walking shoe that’s also great for light workouts. It’s super comfortable, and I’ve been testing it on long walks in Austin and New Zealand on both trails and pavement. Find your perfect pair at Allbirds.com today and use code TIM for free socks with a purchase of $48 or more. Just add a pair of socks to your shopping cart and apply code TIM to make the pair free.

*

This episode is also brought to you by Shopify! Shopify is one of my favorite platforms and one of my favorite companies. Shopify is designed for anyone to sell anywhere, giving entrepreneurs the resources once reserved for big business. In no time flat, you can have a great-looking online store that brings your ideas to life, and you can have the tools to manage your day-to-day and drive sales. No coding or design experience required.

Go to shopify.com/Tim to sign up for a one-dollar-per-month trial period. It’s a great deal for a great service, so I encourage you to check it out. Take your business to the next level today by visiting shopify.com/Tim.

*

This episode is also brought to you by Wealthfront! Wealthfront is an app that helps you save and invest your money. Right now, you can earn 4.3% APY—that’s the Annual Percentage Yield—with the Wealthfront Cash Account. That’s more than eleven times more interest than if you left your money in a savings account at the average bank, according to FDIC.gov. 

It takes just a few minutes to sign up, and then you’ll immediately start earning 4.3% interest on your savings. And when you open an account today, you’ll get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.  Visit Wealthfront.com/Tim to get started.

*

[06:16] The Derek Sivers School of Enough.

[11:24] Scuba diving and empathy lessons in Iceland.

[16:13] Categories we apply to ourselves and others.

[22:46] Derek’s people compass.

[28:14] How to secure your tech independence.

[1:05:19] The unoptimized life.

[1:16:37] The meaning of Derek’s upcoming book, Useful Not True.

[1:32:55] The problem with moral relativism and other -isms.

[1:51:24] Giant leaps.

[2:00:10] Finding and asking mentors for help.

[2:08:18] Games.

[2:12:26] The wisdom of quitting when you’re ahead.

[2:17:13] Why would Derek — never in need of external validation — seek fame?

[2:20:45] What makes Derek so darned interesting?

[2:23:18] Has Derek always been a satisficer?

[2:31:43] Living on the edge case.

[2:35:33] The real question behind “What would you tell your younger self?”

[2:40:29] Giving directions in Antarctica.

[2:41:46] How do you teach an 11-year-old to act like a 16-year-old?

[2:45:45] Parting thoughts.

*

For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.

For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors

Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.

For transcripts of episodes, go to tim.blog/transcripts.

Discover Tim’s books: tim.blog/books.

Follow Tim:

Twitter: twitter.com/tferriss 

Instagram: instagram.com/timferriss

YouTube: youtube.com/timferriss

Facebook: facebook.com/timferriss 

LinkedIn: linkedin.com/in/timferriss

Past guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, I discuss ADHD (Attention-Deficit Hyperactivity Disorder): what it is, the common myths, and the biology and psychology of ADHD.

I discuss both behavioral and pharmacologic treatments for ADHD, and brain-machine interface tools. I also discuss behavioral training protocols that can improve focus in people with ADHD and those without ADHD, and for people of different ages. I discuss the role of dopamine in coordinating 'default-mode' and 'task-related' neural networks, attentional "blinks" (lapses of attention) and how to overcome them, and the role of actual blinks in time perception and attention. Finally, I review some of the prescription and over-the-counter compounds for increasing focus such as Adderall, Ritalin, Modafinil and Armodafinil, the racetams, Alpha-GPC and phosphatidylserine and the role of diet for managing ADHD (and the controversies of diet for ADHD).

The role of cell phones/technology in ADHD and ADHD-like challenges with focus are also discussed. Throughout, both basic science and clinical scenarios, as well as applicable tools and resources are covered.

Read the full show notes for this episode at hubermanlab.com.

Thank you to our sponsors

AG1: https://athleticgreens.com/huberman

LMNT: https://drinklmnt.com/hubermanlab

Waking Up: https://wakingup.com/huberman

Momentous: https://livemomentous.com/huberman

Timestamps

00:00:00 Introduction & Note About Diagnosis  

00:03:44 Sponsors: AG1, LMNT & Waking Up

00:07:56 ADHD vs. ADD: Genetics, IQ, Rates in Kids & Adults  

00:13:00 Attention & Focus, Impulse Control  

00:14:57 Hyper-focus  

00:16:45 Time Perception  

00:18:25 The Pile System  

00:20:00 Working Memory  

00:24:10 Hyper-Focus & Dopamine  

00:26:40 Neural Circuits In ADHD: Default Mode Network & Task-Related Networks  

00:32:57 Low Dopamine in ADHD & Stimulant Use & Abuse  

00:37:10 Sugar, Ritalin, Adderall, Modafinil & Armodafinil  

00:47:00 Non-Prescribed Adderall, Caffeine, Nicotine  

00:49:18 How Stimulants “Teach” the Brains of ADHD Children to Focus  

00:52:00 When To Medicate: A Highly Informed (Anecdotal) Case Study  

00:56:35 Elimination Diets & Allergies In ADHD  

01:04:46 Omega-3 Fatty Acids: EPAs & DHAs  

01:07:00 Modulation vs Mediation of Biological Processes  

01:10:50 Attentional Blinks  

01:16:56 Open Monitoring & 17-Minute Focus Enhancement  

01:22:50 Blinking, Dopamine & Time Perception; & Focus Training  

01:30:10 Reverberatory Neural & Physical Activity  

01:33:40 Adderall, Ritalin & Blink Frequency  

01:35:00 Cannabis  

01:37:30 Interoceptive Awareness  

01:41:15 Ritalin, Adderall, Modafinil, Armodafinil; Smart Drugs & Caffeine: Dangers  

01:48:05 DHA Fatty Acids, Phosphatidylserine  

01:50:54 Ginko Biloba  

01:51:45 Modafinil & Armodafinil: Dopamine Action & Orexin  

01:56:19 Acetylcholine: Circuits Underlying Focus; Alpha-GPC  

01:59:04 L-Tyrosine, (PEA) Phenylethylamine  

02:01:23 Racetams, Noopept  

02:05:15 Transcranial Magnetic Stimulation; Combining Technology & Pharmacology  

02:09:14 Smart Phones & ADHD & Sub-Clinical Focus Issues In Adults & Kids  

02:14:30 Synthesis/Summary  

02:16:10 Support for Podcast & Research, Supplement Resources  

Disclaimer & Dislcosures

Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode serves as a sort of “Dopamine Masterclass”. I discuss the immensely powerful chemical that we all make in our brain and body: dopamine. I describe what it does and the neural circuits involved. I explain dopamine peaks and baselines, and the cell biology of dopamine depletion. I include 14 tools for how to control your dopamine release for sake of motivation, focus, avoiding and combating addiction and depression, and I explain why dopamine stacking with chemicals and behaviors inevitably leads to states of underwhelm and poor performance. I explain how to achieve sustained increases in baseline dopamine, compounds that injure and protect dopamine neurons including caffeine from specific sources. I describe non-prescription supplements for increasing dopamine—both their benefits and risks—and synergy of pro-dopamine supplements with those that increase acetylcholine. 

Read the full show notes for this episode at hubermanlab.com.

Thank you to our sponsors

AG1: https://athleticgreens.com/huberman

LMNT: https://drinklmnt.com/hubermanlab

Waking Up: https://wakingup.com/huberman

Momentous: https://livemomentous.com/huberman

Timestamps

00:00:00 Introduction & Tool 1 to Induce Lasting Dopamine  

00:05:04 Sponsors: AG1, LMNT & Waking Up

00:09:10 Upcoming (Zero-Cost) Neuroplasticity Seminar for Educators  

00:09:58 What Dopamine (Really) Does  

00:15:30 Two Main Neural Circuits for Dopamine  

00:18:14 How Dopamine Is Released: Locally and Broadly  

00:22:03 Fast and Slow Effects of Dopamine  

00:25:03 Dopamine Neurons Co-Release Glutamate  

00:28:00 Your Dopamine History Really Matters  

00:30:30 Parkinson’s & Drugs That Kill Dopamine Neurons. My Dopamine Experience  

00:36:58 Tool 3 Controlling Dopamine Peaks & Baselines  

00:40:06 Chocolate, Sex (Pursuit & Behavior), Nicotine, Cocaine, Amphetamine, Exercise  

00:46:46 Tool 4 Caffeine Increases Dopamine Receptors  

00:49:54 Pursuit, Excitement & Your “Dopamine Setpoint”  

00:56:46 Your Pleasure-Pain Balance & Defining “Pain”  

01:00:00 Addiction, Dopamine Depletion, & Replenishing Dopamine  

01:07:50 Tool 5 Ensure Your Best (Healthy) Dopamine Release  

01:15:28 Smart Phones: How They Alter Our Dopamine Circuits  

01:19:45 Stimulants & Spiking Dopamine: Counterproductive for Work, Exercise & Attention  

01:22:20 Caffeine Sources Matter: Yerba Mate & Dopamine Neuron Protection  

01:24:20 Caffeine & Neurotoxicity of MDMA  

01:26:15 Amphetamine, Cocaine & Detrimental Rewiring of Dopamine Circuits  

01:27:57 Ritalin, Adderall, (Ar)Modafinil: ADHD versus non-Prescription Uses  

01:28:45 Tool 6 Stimulating Long-Lasting Increases in Baseline Dopamine  

01:37:55 Tool 7 Tuning Your Dopamine for Ongoing Motivation  

01:47:40 Tool 8 Intermittent Fasting: Effects on Dopamine  

01:53:09 Validation of Your Pre-Existing Beliefs Increases Dopamine  

01:53:50 Tool 9 Quitting Sugar & Highly Palatable Foods: 48 Hours  

01:55:36 Pornography  

01:56:50 Wellbutrin & Depression & Anxiety  

01:58:30 Tool 10 Mucuna Pruriens, Prolactin, Sperm, Crash Warning  

02:01:45 Tool 11 L-Tyrosine: Dosages, Duration of Effects & Specificity  

02:05:20 Tool 12 Avoiding Melatonin Supplementation, & Avoiding Light 10pm-4am  

02:07:00 Tool 13 Phenylethylamine (with Alpha-GPC) For Dopamine Focus/Energy  

02:08:20 Tool 14 Huperzine A  

02:10:02 Social Connections, Oxytocin & Dopamine Release  

02:12:20 Direct & Indirect Effects: e.g., Maca; Synthesis & Application  

02:14:22 Zero-Cost & Other Ways To Support Podcast & Research  

Disclaimer & Disclosures

Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, I explain how dopamine dynamics — meaning changes and interactions between our baseline and peak levels of dopamine drive our cravings and sense of motivation. I also explain how to leverage dopamine dynamics to overcome procrastination. I cover behavioral, cognitive, nutrition-based and supplementation-based tools to optimize baseline and peak dopamine levels to ensure a persistently motivated state. I also discuss how to boost motivation when you are in a rut, why you might not want to stack behaviors/substances that spike dopamine and how to build and maintain a “growth mindset” for pursuing goals of any kind. Dopamine is an incredibly powerful neuromodulator involved in basic functions (e.g., hunger, romantic attraction, etc.) and feats of cognitive and physical performance; by understanding the dynamics of dopamine, listeners ought to be better positioned to overcome procrastination, maintain motivation, and improve confidence.

For the full show notes, visit hubermanlab.com.

Thank you to our sponsors

AG1: https://athleticgreens.com/huberman

LMNT: https://drinklmnt.com/hubermanlab

Waking Up: https://wakingup.com/huberman

Momentous: https://livemomentous.com/huberman

Timestamps

(00:00:00) Dopamine

(00:02:48) Sponsors: LMNT & Waking Up

(00:06:27) Dopamine Brain Circuits

(00:14:53) Goals & Addiction

(00:17:13) Dopamine Dynamics, “Wave Pool” analogy

(00:20:28) Craving, Motivation, Pursuit & Reward Prediction Error

(00:24:46) Sponsor: AG1 (Athletic Greens)

(00:29:40) Feedback Cues & Reward Contingent Learning, “Scoreboard”

(00:37:40) Addiction; Pleasure & Pain Imbalance

(00:44:55) Dopamine Release & Addictive Substances/Behaviors

(00:50:43) Addiction Recovery, Binding Behaviors

(00:53:25) Tools: Maintain Baseline Dopamine Levels

(01:03:26) Tool: Deliberate Cold Exposure & Dopamine

(01:09:38) Prescriptions & Supplementation: L-Tyrosine, Mucuna Pruriens

(01:18:58) Dopamine Trough Recovery, Postpartum Depression

(01:23:31) Dopamine Dynamics, “Dopamine Stacking”; Intrinsic Motivation

(01:38:10) Making Effort the Reward, Growth Mindset

(01:41:49) Tool: Overcome Procrastination

(01:52:16) Tool: Meditation & Procrastination

(01:57:01) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media

Disclaimer

Learn more about your ad choices. Visit megaphone.fm/adchoices

My guest today is Simone Collins, co-founder with her husband Malcolm of pronatalist.org, an advocacy organisation whose mission is to empower families who choose to preserve and expand human cultural, ethnic, and genetic diversity. They are also the authors of ‘The Pragmatist’s Guide’ series of books, the most recent of which is The Pragmatist’s Guide …

Hosted on Acast. See acast.com/privacy for more information.

Read the full transcript here.

For years, we have been inundated with messages that the world population is out of control as demographers project the global population to reach 10 billion people. But at some point, the rates will decline. People around the world will become older, leading to huge burdens on social services. Malcolm and Simone Collins are pronatalists fighting to stop the fertility collapse that threatens humanity. The husband and wife team are the elite intellectual leaders of the pro-natalist movement, which encourages the bearing of children and support of a higher birth rate to save Western Civilization. Reminiscent of characters from Aldous Huxley's Brave New World, hear Savage in one of his most fascinating interviews to date. We live in a world that is quickly secularizing. How do we fortify our society against the erosion and assault on our traditions?

Learn more about your ad choices. Visit podcastchoices.com/adchoices

In today’s episode, our host, Head of RL, and Meta CTO Andrew “Boz” Bosworth is joined by John Carmack, former Reality Labs Consulting CTO who is currently heading up AGI at Keen Technologies. 

John Carmack is one of the most influential technologists of our time, and his work has shaped multiple generations of software and platforms. As a co-founder of video game company id Software, Carmack developed titles including Wolfenstein 3D, Doom and Quake, which pioneered new approaches to technologies like 3D graphics and online multiplayer gaming.

But Carmack’s impact goes well beyond gaming. In 2013 Carmack left id Software to become the CTO of Oculus VR, where he helped the company pioneer a new era of virtual reality devices. In 2014 Oculus VR was acquired by Meta and Carmack played a key role in the development of the VR technologies that Meta has developed ever since, which formed the foundation for its long term vision to build for the metaverse. 

In short, if you’ve ever played a video game or worn a VR headset, you’ve experienced John Carmack’s legacy. And now, after stepping down from his role at Meta at the end of 2022, Carmack is setting off on a new phase of his career, founding Keen Technologies to work on the pursuit of artificial general intelligence. There’s plenty for Carmack and Boz to talk about, and they cover it all this week, from the incredible new era of AI that’s emerging today to his philosophy on programming, building great software and making users happy.

And as a bonus, Carmack’s recommended reading list for the best sci-fi to understand today’s AI boom, and thoughts on The Last of Us and turning games into TV shows. 

For feedback and suggestions, drop Boz a message @boztank on Instagram or Twitter. Follow John Carmack on Twitter, @id_AA_Carmack.

Support us! https://www.patreon.com/mlst MLST Discord: https://discord.gg/aNPkGUQtc5 In this podcast with the legendary Connor Leahy (CEO Conjecture) recorded in Dec 2022, we discuss various topics related to artificial intelligence (AI), including AI alignment, the success of ChatGPT, the potential threats of artificial general intelligence (AGI), and the challenges of balancing research and product development at his company, Conjecture. He emphasizes the importance of empathy, dehumanizing our thinking to avoid anthropomorphic biases, and the value of real-world experiences in learning and personal growth. The conversation also covers the Orthogonality Thesis, AI preferences, the mystery of mode collapse, and the paradox of AI alignment. Connor Leahy expresses concern about the rapid development of AI and the potential dangers it poses, especially as AI systems become more powerful and integrated into society. He argues that we need a better understanding of AI systems to ensure their safe and beneficial development. The discussion also touches on the concept of "futuristic whack-a-mole," where futurists predict potential AGI threats, and others try to come up with solutions for those specific scenarios. However, the problem lies in the fact that there could be many more scenarios that neither party can think of, especially when dealing with a system that's smarter than humans. https://www.linkedin.com/in/connor-j-leahy/https://twitter.com/NPCollapse Interviewer: Dr. Tim Scarfe (Innovation CTO @ XRAI Glass https://xrai.glass/) TOC: The success of ChatGPT and its impact on the AI field [00:00:00] Subjective experience [00:15:12] AI Architectural discussion including RLHF [00:18:04] The paradox of AI alignment and the future of AI in society [00:31:44] The impact of AI on society and politics [00:36:11] Future shock levels and the challenges of predicting the future [00:45:58] Long termism and existential risk [00:48:23] Consequentialism vs. deontology in rationalism [00:53:39] The Rationalist Community and its Challenges [01:07:37] AI Alignment and Conjecture [01:14:15] Orthogonality Thesis and AI Preferences [01:17:01] Challenges in AI Alignment [01:20:28] Mechanistic Interpretability in Neural Networks [01:24:54] Building Cleaner Neural Networks [01:31:36] Cognitive horizons / The problem with rapid AI development [01:34:52] Founding Conjecture and raising funds [01:39:36] Inefficiencies in the market and seizing opportunities [01:45:38] Charisma, authenticity, and leadership in startups [01:52:13] Autistic culture and empathy [01:55:26] Learning from real-world experiences [02:01:57] Technical empathy and transhumanism [02:07:18] Moral status and the limits of empathy [02:15:33] Anthropomorphic Thinking and Consequentialism [02:17:42] Conjecture: Balancing Research and Product Development [02:20:37] Epistemology Team at Conjecture [02:31:07] Interpretability and Deception in AGI [02:36:23] Futuristic whack-a-mole and predicting AGI threats [02:38:27] Refs: 1. OpenAI's ChatGPT: https://chat.openai.com/ 2. The Mystery of Mode Collapse (Article): https://www.lesswrong.com/posts/t9svvNPNmFf5Qa3TA/mysteries-of-mode-collapse 3. The Rationalist Guide to the Galaxy https://www.amazon.co.uk/Does-Not-Hate-You-Superintelligence/dp/1474608795 5. Alfred Korzybski: https://en.wikipedia.org/wiki/Alfred_Korzybski 6. Instrumental Convergence: https://en.wikipedia.org/wiki/Instrumental_convergence 7. Orthogonality Thesis: https://en.wikipedia.org/wiki/Orthogonality_thesis 8. Brian Tomasik's Essays on Reducing Suffering: https://reducing-suffering.org/ 9. Epistemological Framing for AI Alignment Research: https://www.lesswrong.com/posts/Y4YHTBziAscS5WPN7/epistemological-framing-for-ai-alignment-research 10. How to Defeat Mind readers: https://www.alignmentforum.org/posts/EhAbh2pQoAXkm9yor/circumventing-interpretability-how-to-defeat-mind-readers 11. Society of mind: https://www.amazon.co.uk/Society-Mind-Marvin-Minsky/dp/0671607405

Really fun conversation. Lots of topics I rarely talk about. Building your values, learning and growth, How to Live and my directives, leaving a legacy through what you create, being a life explorer, minimalism

Go subscribe at futurethinkers.org/derek-sivers

Local vs. global, why we travel, singing the counter melody, freedom, expired identities.

Go subscribe at thefarout.life

Big fun questions. Five types of thinking and how to improve them, achieving success and motivation, deliberate daydreaming.

Go subscribe at longdistancelovebombs.com

Why I don’t like holidays, How to Live, how constraints give you more freedom

Go subscribe at productivityist.com

Musician, speaker, writer and entrepreneur, Derek Sivers chats about creating and running CD Baby, reading, mental models, living a meaningful life and that biggest mistake he’s ever made.

--
Want even more? Members get early access, hand-edited transcripts, member-only episodes, and so much more. Learn more here: https://fs.blog/membership/

Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/

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Happy New Year! While I’m currently working hard writing my book and getting ready for Season 5 of the podcast which is just around the corner, I thought I’d share with you a bonus episode taken from the livestreams I recorded during lockdown (which aren’t available anywhere else on the internet). This episode is a conversation with Derek Sivers, a writer, musician and entrepreneur who founded CD Baby, an online CD store for independent musicians, back in 1997. He sold CD Baby in 2007 and has since embarked on other ventures including writing 4 books including Anything You Want: 40 Lessons For A New Kind of Entrepreneur - one of the three books that I've listed as changing my life. This is one of my favourite interviews from the livestreams and his advice on book writing felt particularly timely as I sit two years later writing a book of my own. Enjoy :)

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(00:45) Background and Career

(02:00) Anything You Want Book Discussion

(03:00) Writing a Book

(07:00) Fear of Plagiarism

(09:35) Advice on Writing, Apps and Productivity

(16:05) Current Books Being Written

(19:00) Building Your Own Store

(24:20) Do What Makes You Happy

(27:30) Avoid Quoting From Other People

(32:50) Identity: Music and Being A Doctor

(37:20) Music Theory: Is it really that valuable?

(44:45) Musical Originality

(46:05) Derek’s Singing Journey

(50:15) Ali’s Singing Experiences

(53:00) On Making Friends

(55:45) What Does Friendship Mean?

(59:40) Vulnerability, Exposure and Making Friends

(01:07:00) Talking To People On The Phone

(01:08:45) The Famous Broadway Musical Composer…

(01:13:35) Weird Like Me, Shared Experiences and ‘Burning The Ships’

(01:20:00) Connecting With People and Strangers

(01:23:20) Replying To Everyone

(01:28:30) Replying To People Asking For Advice

(01:33:20) Imposter Syndrome

(01:35:10) Goal Setting in Life and Business

(01:42:45) The Most Powerful Thing to Remember About Goals

(01:45:30) Closing Thoughts

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WATCH

▶️ Watch this episode on YouTube

***

EPISODE DESCRIPTION

Derek Sivers is a musician, producer, circus performer, entrepreneur, TED speaker, and book publisher. He's written four books including How To Live, Hell Yeah Or No, Your Music And People, and Anything You Want.

He's also the founder of CD Baby – the largest seller of independent music online, with $100 million in sales for 150,000 musicians. In 2007, Derek sold that business for $22 million – almost all of which Derek donated to a charitable trust for music education.

In this episode, we talk about how Derek keeps himself focused on ONE project at a time, how to navigate conflicting philosophies, what we can learn from professional musicians, and how creators can pursue balance in our lives.

Full transcript and show notes

Visit Derek Sivers website

See Derek Sivers book recommendations

Follow Derek Sivers on Twitter / YouTube

***

TIMESTAMPS

00:00 - Who is Derek Sivers?

00:27 - Derek is a Monomaniac

01:19 - Derek’s Inspiration for “How To Live”

01:58 - What We Learn Today

02:45 - Derek Has a Singular Focus

04:14 - Is Being a Monomaniac Innate or Learned?

04:57- Don’t Be a Donkey! (Buridan’s Donkey Paradox)

06:54 - Why It’s Important to Prioritize and Sequence in Your Life

07:46 - How to Use Journaling to Prioritize Your Life

09:19 - Life is NOT a Problem to be Solved

12:33 - How Do You Decide What Gets Priority?

17:10 - How to Navigate Conflicting Philosophies

20:10 - Derek’s Process of writing “How To Live”

21:30 - Your Values Change Over Time

23:13 - Breaking Away From Tribalism

24:21 - How to find Balance in Your life

27:49 - STOP Relying on Your Job to Fulfill EVERY Need

30:23 - Derek’s Life as a Musician

31:34 - Momentum is SO Important

34:39 - What Creators Can Learn From Musicians

35:57 - The History of Starbucks (And What You Can Learn From It)

38:22 - Intrinsic VS Extrinsic Motivation

43:10 - Even Rock Stars Have a Boss

44:54 - What Will Derek Do Next?

***

RECOMMENDED NEXT EPISODE

→ #82: Michael Bungay Stanier

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This episode features the profile of Derek Sivers from Tools of Titans, which is now available as an audiobook. This chapter's narrators are Kaleo Griffith (bio) and Ray Porter (profile). To check out the full audiobook of Tools of Titans with 100+ chapters, visit audible.com/ferriss.

Derek Sivers (@sivers) is one of my favorite humans, and I call him often for advice. Think of him as a philosopher-king programmer, master teacher, and merry prankster. Originally a professional musician and circus clown, Derek created CD Baby in 1998. It became the largest seller of independent music online, with $100 million in sales for 150,000 musicians. In 2008, Derek sold CD Baby for $22 million, giving the proceeds to a charitable trust for music education. He is a frequent speaker at the TED Conference, with more than 5 million views of his talks. Since 2011, he has published 34 books, including “Anything You Want,” which I’ve personally read 10+ times. 

***

The audiobooks of Tools of Titans and Tribe of Mentors can be found at audible.com/ferriss

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Well-planned landfills have only recently come into widespread use. Recently, waste managers have found that they work a little too well and now the landfill is being reinvented.

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No one wants to overeat. And certainly no one wants to overeat for years, become overweight, and end up with a high risk of diabetes or heart disease– yet two thirds of Americans do precisely that. 

Stephan is a neuroscientist who, in this episode, will go into the topic of obesity. Stephan provides insights into obesity that are not normally spoken about. He talks in depth about the role of genetics, the brain, and hormones such as leptin that play in the regulation of fat mass. 

He dives deep into the factors that affect body weight, controlling appetite and controlling food intake and provides takeaways for people wanting to take advantage of what we know about the brain’s role in regulating our body weight.

This episode is for anybody wanting to understand the neuroscience of obesity. Why obesity is prevelant in our society and what role the brain plays in obesity. 

• What impacts cravings and appetite
• What is fat
• How obesity has changed over the last 50 years 
• Public health and obesity 
• The brain's role in obesity 
• Obesity as a genetic disorder?  

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The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Neuro Experience podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

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Landfills! Treasures in the trash! Corporate conspiracies! Composting! An instantly classic conversation with the incredibly knowledgeable, frank and wonderful Dr. Robin Nagle of New York University’s Liberal Studies! She is a clinical professor, author, TED speaker and former New York City sanitation worker and truly the best person on Earth to trash talk with. We cover what you can and can’t actually recycle, sticky mustard bottles, drugs in the trash, Swedish Death Cleaning, mobsters and landfills, Bitcoin in the dump, the future of garbage and exactly how screwed we are. Enjoy. 

More episode sources and links

Other episodes you may enjoy: Oceanology (OCEANS), Urban Rodentology (SEWER RATS), Space Archaeology (SPACE JUNK), Critical Ecology (SOCIAL SYSTEMS + ENVIRONMENT), Futurology (THE FUTURE), Disasterology (DISASTERS), Ursinology (BEARS), Eschatology (THE APOCALYPSE), Conservation Technology (EARTH SAVING), Scatology (POOP), Agnotology (IGNORANCE), Xylology (LUMBER)

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Sound editing by Jarrett Sleeper of MindJam Media and Mercedes Maitland of Maitland Audio Productions

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Website by Kelly R. Dwyer

Theme song by Nick Thorburn

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Soil! Dirt! Earth. Dr. Lydia Jennings, aka Native Soil Nerd, breaks down the stuff under our feet and explains everything from mining to why soil can be different colors. Also: medicine from microbes, giving back to the land after extractive processes, collecting samples in urban rivers, elders’ ecological knowledge, planting hot Cheetos, potting soil mysteries, lung fungus, the smell of rain and why gardening makes you happy. Oh and running hundreds of miles for your science. 

Follow Dr. Lydia Jennings on Twitter @1NativeSoilNerd or on Instagram @llcooljennings

Her website: nativesoilnerd.com

Donations went to RisingHearts.org and to Lydia’s film, Will Run for Soil

More episode sources and links

More episodes you may enjoy: Geology (ROCKS), Indigenous Cuisinology (NATIVE COOKING), Indigenous Fire Ecology (GOOD FIRE), Indigenous Fashionology (NATIVE CLOTHING), Experimental Archeology (OLD TOOLS/ATLATLS), Carnivorous Phytobiology (MEAT-EATING PLANTS), Cycadology (RARE PLANT DRAMA), Bisonology (BUFFALO), Foraging Ecology (EATING WILD PLANTS), Critical Ecology (SOCIAL SYSTEMS + ENVIRONMENT)

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Sound editing by Mercedes Maitland & Jarrett Sleeper of MindJam Media

Transcripts by Emily White of The Wordary

Website by Kelly R. Dwyer

Theme song by Nick Thorburn

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TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

•Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Nick Muzyczka passes •CDC planning wastewater testing for polio (CDC) •Wastewater testing for poliovirus (MMWR) •NY state poliovirus wastewater surveillance (NYSDOH) •CDC wastewater poliovirus surveillance in select communities (CDC) •Vast world of viroid-like RNAs (Cell) •Timestamps by Jolene. Thanks!

Kathy – 3B new Milky Way objects, Green comet Rich – Virology under the Microscope—a Call for Rational Discourse Alan – Indie story-driven games series #3: Valiant Hearts: The Great War Vincent – Vaccines and Related Biological Products Advisory Committee Meeting January 26, 2023 – pdf

Florencia – An elegant way to stop deadly Hendra virus spillovers from bats to horses … to us (Nature article)

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli

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Dickson – Baritone Saxophone: Gerry Mulligan. No one else comes close Signature song: Bernie’s Tune Angela – World’s Longest Animal Brianne – Green Comet to Pass By Earth for first time in 50,000 years Alan – Indie games series: Golf Club Wasteland Vincent – Bivalent Covid-19 Vaccines — A Cautionary Tale

Lisa – The River and the Wall

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Paris Marx is joined by Timnit Gebru to discuss the misleading framings of artificial intelligence, her experience of getting fired by Google in a very public way, and why we need to avoid getting distracted by all the hype around ChatGPT and AI image tools.

Timnit Gebru is the founder and executive director of the Distributed AI Research Institute and former co-lead of the Ethical AI research team at Google. You can follow her on Twitter at @timnitGebru.

Tech Won’t Save Us offers a critical perspective on tech, its worldview, and wider society with the goal of inspiring people to demand better tech and a better world. Follow the podcast (@techwontsaveus) and host Paris Marx (@parismarx) on Twitter, and support the show on Patreon.

The podcast is produced by Eric Wickham and part of the Harbinger Media Network.

Also mentioned in this episode:

• Please participate in our listener survey this month to give us a better idea of what you think of the show: https://forms.gle/xayiT7DQJn56p62x7
• Timnit wrote about the exploited labor behind AI tools and how effective altruism is pushing a harmful idea of AI ethics.
• Karen Hao broke down the details of the paper that got Timnit fired from Google.
• Emily Tucker wrote an article called “Artifice and Intelligence.”
• In 2016, ProPublica published an article about technology being used to “predict” future criminals that was biased against black people.
• In 2015, Google Photos classified black women as “gorillas.” In 2018, it still hadn’t really been fixed.
• Artists have been protesting AI-generated images that train themselves on their work and threaten their livelihoods.
• OpenAI used Kenyan workers paid less than $2 an hour to try to make ChatGPT less toxic.
• Zachary Loeb described ELIZA in his article about Joseph Weizenbaum’s work and legacy.

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Den danske AI-start-up ABZU bekæmper brystcancer med explainable AI. Den kunstige intelligens skal ud af den sorte box, så vi kan forstå, hvordan den er nået til sit resultat, og hvad vi kan bruge det til.

ABZU's stifter vil have den videnskablige tænkning tilbage i udviklingen af teknologi. Der er grundliggende forskel på et neuralt netværk, som forudsiger dit næste bogkøb på Amazon og AI, der kan analysere dødeligheden af brystkræft og samtidig give forskerne viden og ideer til at udvikle en effektiv behandling.

Techtopia møder ABZUs direktør og stifter Casper Wilstrup.

People talk a lot about making sure you get all the nutrients you need on a plant-based diet, but what if we're looking at it all wrong? What if the bigger concern for everyone, not just vegans, is overnutrition?

In today's episode we chat with Julieanna Hever and Ray Cronise, authors of Plant-Based Nutrition (Idiot's Guide) on their approach to eating healthy for the long-haul.

People generally think of self-compassion as a "soft" emotion that helps us comfort, reassure, and nurture ourselves. Today a pioneer in the field of compassion research, Dr. Kristin Neff, joins the show to explore the fierce side of self-compassion, including how it can help us draw healthy boundaries, take necessary action, and stand against injustice.

About Our Guest: Dr. Kristin Neff is an Associate Professor at the University of Texas at Austin. She conducted the first empirical studies on self-compassion almost twenty years ago, and is the author of Self-Compassion: The Proven Power of Being Kind to Yourself.  On June 15th she'll be releasing her new book: Fierce Self-Compassion: How Women Can Harness Kindness to Speak Up, Claim Their Power and Thrive.

Watch our conversation on YouTube here!

Support the Podcast: We're now on Patreon! If you'd like to support the podcast, follow this link.

Key Topics:

1:50: How is fierce self-compassion different from “typical” self-compassion?

5:50: The balance of fierceness and tenderness.

7:45: The importance of fierceness for women.

17:15: Practices that support fierce self-compassion.

20:30: Applying fierce self-compassion internally.

25:40: The harms of traditional gender role socialization.

32:10: What behaviors were you rewarded for?

34:45: Research on the value of self-compassion.

40:40: The impact of self-compassion on motivation. 

45:15: Committing to our own well being.

50:45: How men can support women.

55:00: A message to your younger self.

57:15: Recap

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Associate Professor Kristin Neff is widely recognized as one of the world's leading experts on self-compassion, being the first one to operationally define and measure the construct almost twenty years ago. She received her doctorate from Berkeley, and is currently an Associate Professor in Psychology at the University of Texas. She has two books; Self-Compassion: The Proven Power of Being Kind to Yourself (2011) and her new 2021 book Fierce Self-Compassion: How Women Can Harness Kindness to Speak Up, Claim Their Power and Thrive.

She is also co-founder of the non-profit Center for Mindful Self-Compassion. In conjunction with her colleague Dr. Chris Germer they have developed an empirically supported training program called Mindful Self-Compassion and Teaching the Mindful Self-Compassion Program: A Guide for Professionals. You can find all her resources, books, guided practices on her website https://self-compassion.org/.

For the Master/Grad Diploma/Grad Cert in Lifestyle Medicine at James Cook University, check out:

https://www.jcu.edu.au/courses/master-of-lifestyle-medicine/

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https://www.jcu.edu.au/courses/graduate-certificate-of-lifestyle-medicine

If you find this podcast valuable, rating it 5 stars and leaving a review on your podcast app is appreciated.

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Thank you for listening.

In December 2019, DeepMind’s AI system, AlphaFold, solved a 50-year-old grand challenge in biology, known as the protein-folding problem. A headline in the journal Nature read, “It will change everything” and the President of the UK's Royal Society called it a “stunning advance [that arrived] decades before many in the field would have predicted”. In this episode, Hannah uncovers the inside story of AlphaFold from the people who made it happen and finds out how it could help transform the future of healthcare and medicine.

For questions or feedback on the series, message us on Twitter @DeepMind or email podcast@deepmind.com. 

Interviewees: DeepMind’s Demis Hassabis, John Jumper, Kathryn Tunyasunakool and Sasha Brown; Charles Mowbray and Monique Wasuna of the Drugs for Neglected Diseases initiative (DNDi]) & John McGeehan of the Centre for Enzyme Innovation at the University of Portsmouth

Credits

Presenter: Hannah Fry

Series Producer: Dan Hardoon

Production support: Jill Achineku

Sounds design: Emma Barnaby

Music composition: Eleni Shaw

Sound Engineer: Nigel Appleton

Editor: David Prest

Commissioned by DeepMind

Thank you to everyone who made this season possible! 

Further reading: 

AlphaFold blog, DeepMind: https://deepmind.com/blog/article/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology

AlphaFold case study, DeepMind: https://deepmind.com/research/case-studies/alphafold

It will change everything, Nature: https://www.nature.com/articles/d41586-020-03348-4

AlphaFold Is The Most Important Achievement In AI—Ever, Forbes: https://www.forbes.com/sites/robtoews/2021/10/03/alphafold-is-the-most-important-achievement-in-ai-ever/?sh=359278426e0a

Bacteria found to eat PET plastics, NewScientist: https://www.newscientist.com/article/2080279-bacteria-found-to-eat-pet-plastics-could-help-do-the-recycling/

Protein Structure Prediction Center: https://predictioncenter.org/

An interview with Professor John McGeehan, BBSRC: https://bbsrc.ukri.org/news/features/enzyme-science/an-interview-with-professor-john-mcgeehan/

John McGeehan profile, University of Portsmouth: https://researchportal.port.ac.uk/en/persons/john-mcgeehan

Drugs for Neglected Diseases initiative (DNDi): https://dndi.org/

A doctor’s dream, DNDi: https://www.youtube.com/watch?v=Tk31iucWYdE

The Curious Cases of Rutherford and Fry, BBC: https://www.bbc.co.uk/programmes/b07dx75g/episodes/downloads

Hannah Fry: 

https://hannahfry.co.uk/

Please leave us a review on Spotify or Apple Podcasts if you enjoyed this episode. We always want to hear from our audience whether that's in the form of feedback, new idea or a guest recommendation!

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This episode is about AlphaFold and the impact it is having on junior scientists. I spoke with a group of them from different labs at the Max Planck Institute of Biochemistry. I spoke with Dr Isabell Bludau, a postdoctoral fellow and computational biologist in the lab of Dr Matthias Mann, Dr. Bastian Bräuning, a postdoctoral fellow and project group leader in the Department of Brenda Schulman and Juan Restropo a PhD student in the lab of Dr Jürgen Cox. 

Biology and AI for predicting protein structure. This is a chat with conversation with some members of the Rost lab  at the Technical University of Munich. Dr. Maria Littmann, postdoctoral fellow, and PhD students Konstantin Weissennow and Michael Heinzinger and Dr Burkhard Rost, principal investigator.  We talked about AlphaFold, a computational approach from DeepMind Technologies that has changed the way and the speed at which proteins can be predicted. 

Proteins are twirly, curly, dynamic structures. Crucial for life, complicated to study. Predicting protein structure has been tough but it's now easier as AlphaFold enters the scene. That doesn't mean that AlphaFold has solved all challenges, of course. AlphaFold was developed by DeepMind Technologies, a company that was bought by Google in 2014. Lots of protein puzzles remain. Dr. Janet Thornton from the European Bioinformatics Institute and Dr David Jones of University College London talk about what AlphaFold can do and what it cannot yet do. They look forward, backward and all around on this subject. He says, laughing, he has "extreme cautious optimism" about the prospects of this field. You can also find my feature story about protein structure prediction, which is the Nature Methods method of the year for 2021, here: https://www.nature.com/articles/s41592-021-01359-1
 

Eric Topol speaks with DeepMind CEO Demis Hassabis about harnessing the potential of AI in health and medicine.

This podcast is intended for US healthcare professionals only.

To read a full transcript of this episode or to comment please visit:

https://www.medscape.com/features/public/machine

Eric J. Topol, MD, Director, Scripps Translational Science Institute; Professor of Molecular Medicine, The Scripps Research Institute, La Jolla, California; Editor-in-Chief, Medscape

Demis Hassabis, PhD, Founder and CEO, DeepMind, London, United Kingdom

https://www.deepmind.com/

You may also like:

Medscape's Chief Cardiology Correspondent Dr John M. Mandrola's This Week In Cardiology

https://www.medscape.com/twic

Discussions on topics at the core of cardiology and the practice of medicine with Dr Robert A. Harrington and guests on The Bob Harrington Show

https://www.medscape.com/author/bob-harrington

For questions or feedback, please email: news@medscape.net

Demis Hassabis is the CEO and co-founder of DeepMind. Please support this podcast by checking out our sponsors:
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DeepMind’s Instagram: https://instagram.com/deepmind
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Plasma control paper: https://nature.com/articles/s41586-021-04301-9
Quantum simulation paper: https://science.org/doi/10.1126/science.abj6511
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– Medium: https://medium.com/@lexfridman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:17) – Turing Test
(14:43) – Video games
(36:18) – Simulation
(38:29) – Consciousness
(43:29) – AlphaFold
(57:09) – Solving intelligence
(1:09:28) – Open sourcing AlphaFold & MuJoCo
(1:19:34) – Nuclear fusion
(1:23:38) – Quantum simulation
(1:26:46) – Physics
(1:30:13) – Origin of life
(1:34:52) – Aliens
(1:42:59) – Intelligent life
(1:46:08) – Conscious AI
(1:59:23) – Power
(2:03:53) – Advice for young people
(2:11:59) – Meaning of life

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Thank you so much. Happy listening and reading!

- Benjamin

Today we talk about Emerson and his essay about self reliance. 

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